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This article is a fully referenced research review to overview progress in unraveling the details of the evolutionary Tree of Life, from life's first occurrence in the RNA-era, to humanity's emergence and diversification, through migration and intermarriage.

The Tree of Life, in biological terms, has come to be identified with the evolutionary tree of biological diversity.

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The evolutionary tree of life is our immortal progenitor, not just of ourselves, but of all the species with which we co-depend, so we need to both understand it and protect it for the future generations.An ingenious piece of genetic software engineering evolved in which the amber stop codon UAG is overridden if the m-RNA possesses a motif called SECIS (selenocysteine insertion sequence).Selenocysteine is then inserted instead of termination, and translation continues.It is this tree which represents the climax fruitfulness of the biosphere and the genetic foundation of our existence, embracing not just higher Eucaryotes, plants, animals and fungi, but Protista, Eubacteria and Archaea, the realm, including the extreme heat and salt-loving organisms, which appears to lie almost at the root of life itself.The notion of a tree of evolution veertically down te generations has become complicated by evidence for promiscuous horizontal gene transfer and for genetic symbiosis at the root of the eucaryote tree.

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